CRYAB ELISA Kit for Human(Homo sapiens) | EIAab.comCRYAB ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CRYAB(Gene name) > Human

CRYAB (Gene name),

Alpha-crystallin B chain (Protein name ), CRYAB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CRYAB(CRYA2);

Protein name:

Alpha-crystallin B chain;

Alternative:

Heat shock protein beta-5(HspB5);Alpha(B)-crystallin;Rosenthal fiber component;Renal carcinoma antigen NY-REN-27;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Aggregates with homologous proteins, including CRYAA and the small heat shock protein HSPB1, to form large heteromeric complexes. Interacts with HSPBAP1 and TTN/titin.

Function:

May contribute to the transparency and refractive index of the lens.

Subcellular Location:

Cytoplasm Nucleus Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Protein Attributes:

Sequence length:

175

Sequence:

50:

100:

150:

175:

QVSGPERTIP | ITREEKPAVT | AAPKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P02511

Pfam:

PF00525

MIM:

123590

UniGene:

Hs.53454

STRING:

9606.ENSP00000227251

SMR:

P02511

KEGG:

hsa:1410

Uniprot:

P02511

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ELISA Kit for Human Alpha-crystallin B chain

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E0194h

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96T

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ELISA Kit for Human Alpha-crystallin B chain

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E0194b

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96T

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ELISA Kit for Human Alpha-crystallin B chain

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E0194m

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96T

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ELISA Kit for Human Alpha-crystallin B chain

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E0194r

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ELISA Kit for Human Alpha-crystallin B chain

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E0194p

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96T

ELISA Kit for Human Alpha-crystallin B chain

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ELISA Kit for Human Alpha-crystallin B chain

Cat.:

E0194c

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96T

CLIA Kit for Human Alpha-crystallin B chain

Cat.:

U0194c

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96T

CLIA Kit for Human Alpha-crystallin B chain

Cat.:

U0194m

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96T

CLIA Kit for Human Alpha-crystallin B chain

Cat.:

U0194b

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MSDS:

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Packing:

96T

CLIA Kit for Human Alpha-crystallin B chain

Cat.:

U0194p

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Packing:

96T

CLIA Kit for Human Alpha-crystallin B chain

Cat.:

U0194r

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Packing:

96T

CLIA Kit for Human Alpha-crystallin B chain

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CLIA Kit for Human Alpha-crystallin B chain

Cat.:

U0194h

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96T

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Polyclonal Antibody for Human Alpha-crystallin B chain

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P0194Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-crystallin B chain

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P0194Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-crystallin B chain

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P0194Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-crystallin B chain

Monoclonal Antibody for Human Alpha-crystallin B chain

Protein for Human Alpha-crystallin B chain

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"The primary structure of the B2 chain of human alpha-crystallin."
Kramps J.A. , de Man B.M. , de Jong W.W.
FEBS Lett.74:82-84(1977) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PROTEIN SEQUENCE
2.

"Human alpha B-crystallin gene and preferential promoter function in lens."
Dubin R.A. , Ally A.H. , Chung S. , Piatigorsky J.
Genomics7:594-601(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA."
Iwaki A. , Iwaki T. , Goldman J.E. , Ogomori K. , Tateishi J. , Sakaki Y.
Neurosci. Lett.140:89-92(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

Yu W. , Sarginson J. , Gibbs R.A.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Heart.
10.

"Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle."
Kato K. , Shinohara H. , Goto S. , Inaguma Y. , Morishita R. , Asano T.
J. Biol. Chem.267:7718-7725(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-24; 35-66 AND 118-175;ASSOCIATION WITH HSPB1
tissue: Pectoralis muscle.
11.

"Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."
Lampi K.J. , Ma Z. , Shih M. , Shearer T.R. , Smith J.B. , Smith D.L. , David L.L.
J. Biol. Chem.272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 57-66
12.

"The major protein expression profile and two-dimensional protein database of human heart."
Kovalyov L.I. , Shishkin S.S. , Efimochkin A.S. , Kovalyova M.A. , Ershova E.S. , Egorov T.A. , Musalyamov A.K.
Electrophoresis16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 83-89 AND 164-172
tissue: Heart.
13.

"Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain."
Iwaki T. , Kume-Iwaki A. , Liem R.K.H. , Goldman J.E.
Cell57:71-78(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-175
14.

"Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens."
Fujii N. , Ishibashi Y. , Satoh K. , Fujino M. , Harada K.
Biochim. Biophys. Acta1204:157-163(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RACEMIZATION/ISOMERIZATION OF SPECIFIC ASP
15.

"Post-translational modifications of water-soluble human lens crystallins from young adults."
Miesbauer L.R. , Zhou X. , Yang Z. , Yang Z. , Sun Y. , Smith D.L. , Smith J.B.
J. Biol. Chem.269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-19; SER-45 AND SER-59;MASS SPECTROMETRY
16.

"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J. , Gordan J.D. , Williamson B. , Stockert E. , Bander N.H. , Jongeneel C.V. , Gure A.O. , Jaeger D. , Jaeger E. , Knuth A. , Chen Y.-T. , Old L.J.
Int. J. Cancer83:456-464(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN
tissue: Renal cell carcinoma.
17.

"The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."
Hanson S.R.A. , Hasan A. , Smith D.L. , Smith J.B.
Exp. Eye Res.71:195-207(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY;SUSCEPTIBILITY TO OXIDATION;PHOSPHORYLATION
18.

"Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27."
Liu C. , Gilmont R.R. , Benndorf R. , Welsh M.J.
J. Biol. Chem.275:18724-18731(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSPBAP1
19.

"Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans."
Berry V. , Francis P. , Reddy M.A. , Collyer D. , Vithana E. , MacKay I. , Dawson G. , Carey A.H. , Moore A. , Bhattacharya S.S. , Quinlan R.A.
Am. J. Hum. Genet.69:1141-1145(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CTRCT16
20.

"Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease."
Kato K. , Inaguma Y. , Ito H. , Iida K. , Iwamoto I. , Kamei K. , Ochi N. , Ohta H. , Kishikawa M.
J. Neurochem.76:730-736(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-45 AND SER-59
21.

"In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92."
Lapko V.N. , Smith D.L. , Smith J.B.
Protein Sci.10:1130-1136(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-92
22.

"Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations."
Selcen D. , Engel A.G.
Ann. Neurol.54:804-810(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MFM2
23.

"Association of the chaperone alphaB-crystallin with titin in heart muscle."
Bullard B. , Ferguson C. , Minajeva A. , Leake M.C. , Gautel M. , Labeit D. , Ding L. , Labeit S. , Horwitz J. , Leonard K.R. , Linke W.A.
J. Biol. Chem.279:7917-7924(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTN
24.

"HSPB7 is a SC35 speckle resident small heat shock protein."
Vos M.J. , Kanon B. , Kampinga H.H.
Biochim. Biophys. Acta1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
25.

"Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications."
Srinivas P. , Narahari A. , Petrash J.M. , Swamy M.J. , Reddy G.B.
IUBMB Life62:693-702(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
26.

"Infantile muscular dystrophy in Canadian aboriginals is an alphaB-crystallinopathy."
Del Bigio M.R. , Chudley A.E. , Sarnat H.B. , Campbell C. , Goobie S. , Chodirker B.N. , Selcen D.
Ann. Neurol.69:866-871(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MFMFIH-CRYAB
27.

"Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function."
Nagaraj R.H. , Nahomi R.B. , Shanthakumar S. , Linetsky M. , Padmanabha S. , Pasupuleti N. , Wang B. , Santhoshkumar P. , Panda A.K. , Biswas A.
Biochim. Biophys. Acta1822:120-129(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-92 AND LYS-166
28.

"Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry."
Karmakar S. , Das K.P.
Protein J.31:623-640(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;ZINC-BINDING SITES
29.

"A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy."
Vicart P. , Caron A. , Guicheney P. , Li Z. , Prevost M.-C. , Faure A. , Chateau D. , Chapon F. , Tome F. , Dupret J.-M. , Paulin D. , Fardeau M.
Nat. Genet.20:92-95(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MFM2 GLY-120
30.

"Alteration of protein-protein interactions of congenital cataract crystallin mutants."
Fu L. , Liang J.J.-N.
Invest. Ophthalmol. Vis. Sci.44:1155-1159(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS MFM2 GLY-120
31.

"Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20."
Bagneris C. , Bateman O.A. , Naylor C.E. , Cronin N. , Boelens W.C. , Keep N.H. , Slingsby C.
J. Mol. Biol.392:1242-1252(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 67-157;HOMODIMERIZATION
32.

"Alpha B-crystallin mutation in dilated cardiomyopathy."
Inagaki N. , Hayashi T. , Arimura T. , Koga Y. , Takahashi M. , Shibata H. , Teraoka K. , Chikamori T. , Yamashina A. , Kimura A.
Biochem. Biophys. Res. Commun.342:379-386(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1II HIS-157
33.

"alphaB-crystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands."
Pilotto A. , Marziliano N. , Pasotti M. , Grasso M. , Costante A.M. , Arbustini E.
Biochem. Biophys. Res. Commun.346:1115-1117(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1II SER-154
34.

"A novel CRYAB mutation resulting in multisystemic disease."
Sacconi S. , Feasson L. , Antoine J.C. , Pecheux C. , Bernard R. , Cobo A.M. , Casarin A. , Salviati L. , Desnuelle C. , Urtizberea A.
Neuromuscul. Disord.22:66-72(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MFM2 HIS-109

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